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  • Title: Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17-hydroxyprogesterone.
    Author: Barnes ND, Atherden SM.
    Journal: Arch Dis Child; 1972 Feb; 47(251):62-5. PubMed ID: 4336233.
    Abstract:
    Measurement of plasma 17-hydroxyprogesterone by a simple competitive protein-binding assay has proved of value in the diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Children with untreated adrenal hyperplasia had high resting levels from as early as the 6th day of life, and children treated with suppressive doses of cortisone showed a rise after adrenal stimulation with tetracosactrin. The method also promises to enhance the ease and precision with which the condition can be managed.
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