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  • Title: Methotrexate for psoriasis-revisited.
    Author: O'Donoghue MN, Melcher RE.
    Journal: Am Fam Physician; 1979 Apr; 19(4):99-102. PubMed ID: 433728.
    Abstract:
    If maximum medical management-hospitalization, tar and sunlight therapy, topical steroids with plastic-wrap occlusion--is not effective, and PUVA is not available, methotrexate therapy should be considered, especially in a patient with severe psoriatic arthritis. It should be used if systemic steroids are inadvisable and if the patient has a normal liver biopsy and no history of alcohol excess. The least toxic and most effective method of administration is three divided doses every 12 hours, once a week.
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