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  • Title: 1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats.
    Author: Holick MF, Garabedian M, DeLuca HF.
    Journal: Science; 1972 Jun 09; 176(4039):1146-7. PubMed ID: 4338462.
    Abstract:
    Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization.
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