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  • Title: Antibody responses to herpesviruses (EBV, HSV and CMV) in cancer patients given cultured lymphoblastoid cells.
    Author: Minowada J, Moore GE, Gerner RE, Matheisz JS.
    Journal: Clin Exp Immunol; 1972 May; 11(1):43-50. PubMed ID: 4338950.
    Abstract:
    Infusion of cultured human lymphoblastoid cells into ten patients with advanced malignancies resulted in a significant rise in antibody titre to Epstein-Barr virus in all ten. There was a significant rise in antibody titre to herpes simplex virus (HSV) in six of the ten patients. The four patients who did not respond in their antibody to HSV had no detectable HSV antibody before the cell infusion. In contrast, four patients had detectable antibody titre to cytomegalovirus (CMV) prior to the cell infusion; none of the ten showed a rise in CMV antibody after cell infusion. Observed antibody responses to EBV and HSV occurred regardless of the presence or absence of detectable herpesviruses in the lymphoblastoid cell lines infused. Six of the ten patients, negative for the heterophile antibody before cell infusion, developed a significant titre of the heterophile antibody after infusion. Except for the heterophile antibody response, the failure to detect IgM antibody to Epstein-Barr virus and to induce antibody to herpes simplex virus in the nonimmune patients suggests that the observed antibody responses are secondary responses.
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