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  • Title: Collagenase: localization in polymorphonuclear leukocyte granules in the rabbit.
    Author: Robertson PB, Ryel RB, Taylor RE, Shyu KW, Fullmer HM.
    Journal: Science; 1972 Jul 07; 177(4043):64-5. PubMed ID: 4339426.
    Abstract:
    Polymorphonuclear leukocyte granules were submitted to zonal fractionation through a discontinuous sucrose gradient. Azurophilic and specific granules were enzymatically characterized by peroxidase and alkaline phosphatase activity, respectively. The enzymes formed modal distributions like those reported by others. Collagenase activity was consistently associated with the specific granules containing alkaline phosphatase.
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