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  • Title: Experience in the laboratory detection of the carrier state of classic hemophilia.
    Author: Hohn DE, Fisher LM.
    Journal: Am J Med Technol; 1979 Apr; 45(4):294-6. PubMed ID: 433979.
    Abstract:
    The predictive odds for suspected carriers of hemophilia have been calculated using data derived from normal and known carrier populations. For each individual, the concentration of Factor VIII-related antigen and Factor VIII biological (procoagulant) activity was measured and the data were studied by linear discriminant analysis. Forty-five suspected carriers were evaluated, with 31 percent (14/45) classified as carriers. Using Factor VIII procoagulant activity alone, 18 percent (8/45) appeared as carriers, while the ratio method of activity level to antigen level showed 44 percent (20/45).
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