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  • Title: In vitro synthesis of procollagen on polysomes.
    Author: Kerwar SS, Kohn LD, Lapiere CM, Weissbach H.
    Journal: Proc Natl Acad Sci U S A; 1972 Sep; 69(9):2727-31. PubMed ID: 4341706.
    Abstract:
    The major collagenous products synthesized in a cell-free polysome preparation are pro-alpha1 and pro-alpha2, formed in a ratio of 2:1. They are the precursor forms of alpha1 and alpha2 chains of normal connective-tissue collagen that are also formed in small amounts. A procollagen peptidase activity has been demonstrated in the supernatant fraction that can account for the formation of alpha1 and alpha2 chains from their precursors. The polysomal system is activated by a salt extract of reticulocyte ribosomes and is inhibited by aurintricarboxylic acid, suggesting that the polysomes are able to initiate protein synthesis.
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