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  • Title: The auto-immunogenicity of articular cartilage.
    Author: Langer F, Gross AE, Greaves MF.
    Journal: Clin Exp Immunol; 1972 Sep; 12(1):31-7. PubMed ID: 4343377.
    Abstract:
    Rats injected with syngeneic chondrocytes or cartilage shavings develop autoreactivity as assayed by the leucocyte migration inhibition test. It is suggested that chondrocyte specific differentiation antigen(s), normally sequestered from the immune system, once exposed experimentally by enzyme treatment or in some human pathological situations are recognized as foreign immunogens and induce a lymphocyte response.
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