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  • Title: [Abnormalities of fibrin formation in benign viral hepatitis (author's transl)].
    Author: Thabaut A, Laverdant C, Durosoir JL, Cristau P, Essioux J, Molinié C.
    Journal: Ann Med Interne (Paris); 1979; 130(1):35-8. PubMed ID: 434713.
    Abstract:
    Abnormalities of fibrin formation were studied in 42 young adult patients with benign viral hepatitis. It was observed that there was a constant increase in thrombin time and reptilase time, evoking an abnormality of the second stage of fibrin formation, or the aggregation of fibrin monomers. This abnormality is not associated with the presence of inhibitors in the patients' serums, and is maximum at an alkaline pH. The hypothesis of an abnormality of the fibrinogen molecule, a dysfibrinogenemia, is the most likely cause, and this has to be confirmed by biochemical and immunochemical studies.
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