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  • Title: Nephrotic syndrome associated with methimazole therapy.
    Author: Reynolds LR, Bhathena D.
    Journal: Arch Intern Med; 1979 Feb; 139(2):236-7. PubMed ID: 434980.
    Abstract:
    Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. We report the development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves' disease. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, we propose that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.
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