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  • Title: A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate.
    Author: Sanders R, McGeoch D.
    Journal: Proc Natl Acad Sci U S A; 1973 Apr; 70(4):1017-21. PubMed ID: 4352217.
    Abstract:
    We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli. Genetic data have indicated that the suppressor of the P(-) mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3':5'-cyclic GMP in addition to their normal effector, 3':5'-cyclic AMP.
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