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  • Title: Action of botulinum toxin on transmission from sympathetic nerves to the vas deferens.
    Author: Holman ME, Spitzer NC.
    Journal: Br J Pharmacol; 1973 Feb; 47(2):431-3. PubMed ID: 4352870.
    Abstract:
    Botulinum toxin (Type A) depressed or abolished transmission from postganglionic nerves to smooth muscle of isolated preparations of guinea-pig and mouse vas deferens. The time course of blockade was 2 to 6 times slower than that observed with the same concentration of the same batch of toxin on the rat diaphragm. Spontaneous excitatory junction potentials were still observed after 7 h exposure, indicating that the smooth muscle membrane was still able to respond to noradrenaline. Depression of transmission is probably due to a presynaptic action of unknown nature.
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