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  • Title: Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture.
    Author: Albert KS, Welch RD, DeSante KA, DiSanto AR.
    Journal: J Pharm Sci; 1979 May; 68(5):586-8. PubMed ID: 435335.
    Abstract:
    Oral coadministration of a single 250-mg tetracycline capsule and 60 ml of a bismuth subsalicylate antidiarrheal mixture reduced tetracycline absorption by 34% without appearing to perturb its absorption or disposition rate. A pronounced increase in intersubject tetracycline absorption variability also was noted. Apparently, the reduction in tetracycline bioavailability previously reported with a kaolin-pectin suspension is not peculiar to kaolin-pectin but can be expected with almost any antidiarrheal whose mechanism of action is adsorptive in nature.
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