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Title: Stimulation of transplantation immunity and plasma cell reaction by interferon in mice. Author: Skurkovich SV, Klinova EG, Aleksandrovskaya IM, Levina NV, Arkhipova NA, Bulicheva TI. Journal: Immunology; 1973 Aug; 25(2):317-22. PubMed ID: 4354827. Abstract: It is assumed that interferon is a necessary component of the formation of immunological reactivity. At the same time interferon may serve as a factor stimulating immunity as a whole. Administration of interferon to mice, recipients of skin allografts, brings about acceleration of rejection process and stimulation of the cytotoxic activity of lymphocytes of mice towards target cells. With the repeated transplantations to mice treated with interferon in the first grafting, acceleration of rejection of new grafts (the `second set' phenomenon) is observed. Intrasplenic inoculation of interferon to mice at the time of antigen administration results in intensified plasma cell reaction in the spleens.[Abstract] [Full Text] [Related] [New Search]