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  • Title: Collagen synthesis: localization of prolyl hydroxylase in tendon cells detected with ferritin-labeled antibodies.
    Author: Olsen BR, Berg RA, Kishida Y, Prockop DJ.
    Journal: Science; 1973 Nov 23; 182(4114):825-7. PubMed ID: 4355681.
    Abstract:
    An improved procedure was employed for linking ferritin to antibodies against prolyl hydroxylase, the enzyme that synthesizes the hydroxyproline in collagen. By electron microscopy, the enzyme was then found to be localized in cisternae of the rough endoplasmic reticulum of embryonic tendon cells; this indicates that hydroxylation of proline occurs while newly synthesized polypeptides are fed into the cisternae.
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