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  • Title: [Radiosensitivity of colony-forming units of dog bone marrow in agar cultures].
    Author: Gorbunova IA.
    Journal: Biull Eksp Biol Med; 1979 Apr; 87(4):340-2. PubMed ID: 435625.
    Abstract:
    Radiosensitivity of the bone-marrow colony-forming cells was determined by a modified method of hemopoietic cells cloning in vivo in semihard agar gel in diffusion chambers. Do for the commited precursor cells of granulopoiesis (CFUc) was 144 +/- 14.8 rad (n = 0.8), and Do for the precursor cells forming "stellate" colonies of fibroblast-like cells (PFUf) was 468 +/- 35.8 rad (n == 0.9). A conclusion was drawn that PFUf were referred to the class of stromal precursors of the hemopoietic organs. This system can be applied for a simultaneous study of the hemopoietic and stromal precursor cells in dogs.
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