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  • Title: Restricted replication of vesicular stomatitis virus in human lymphoblastoid cells.
    Author: Nowakowski M, Bloom BR, Ehrenfeld E, Summers DF.
    Journal: J Virol; 1973 Dec; 12(6):1272-8. PubMed ID: 4357508.
    Abstract:
    Replication of vesicular stomatitis virus (VSV) is restricted in one human lymphoblastoid cell line (Raji), but not in another similar cell line (Wil-2), compared with growth in HeLa cells. This restriction is characterized by a low proportion of cells yielding infectious virus and is associated with limited production of 42S virion RNA. Primary transcription of 13S and 26S VSV-specific RNA is not restricted in Raji cells, and the 13S RNA produced contains adenylate-rich sequences. This suggests that the block in Raji cells involves some step required for the replication of virion RNA.
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