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  • Title: Transformation of cultured mammalian cells by viable herpes simplex virus subtypes 1 and 2.
    Author: Garfinkle B, McAuslan BR.
    Journal: Proc Natl Acad Sci U S A; 1974 Jan; 71(1):220-4. PubMed ID: 4359329.
    Abstract:
    A continuous line of rodent cells carrying the genome of the Rous sarcoma virus was stably transformed by exposure to viable herpes simplex virus of either subtype 1 or 2. Transformation was accompanied by alteration of morphology, growth characteristics, acquisition of a thymidine kinase activity (EC 2.7.1.21) resembling the corresponding specific activity of the enzyme in the herpes simplex virus, and capacity to express continuously some antigens specific for herpes simplex virus.
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