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  • Title: Platelet monoamine oxidase in a pedigree with schizophrenia: an interlaboratory project.
    Author: Ask AL, Böök JA, Heyden T, Ross SB, Unge C, Wetterberg L, Eiduson S, Kobayashi K.
    Journal: Clin Genet; 1979 Apr; 15(4):289-99. PubMed ID: 436326.
    Abstract:
    Conflicting reports on the association between platelet MAO activity and schizophrenia prompted a critical review and determinations on identical samples at one laboratory in Sweden and one in the U.S.A. Samples originated from eight schizophrenics and 27 relatives belonging to a large pedigree, thus ensuring biological homogeneity. In the USA laboratory, a significantly lower MAO activity was found in the schizophrenics when benzylamine or beta-phenylethylamine was used as substrate (but not with tryptamine), while a similar result was obtained in the Swedish laboratory when tryptamine was used (but not with benzylamine or beta-phenylethylamine). Comparisons between materials examined in different laboratories do not seem meaningful until differences in methodologies have been clarified. At present there is neither proof nor disproof of MAO being a "genetic marker" for vulnerability to the schizophrenic disorder.
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