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  • Title: Abnormal lymphocyte responses in residents of a town with a cluster of Hodgkin's disease.
    Author: Plouffe JF, Silva J, Schwartz RS, Callen JP, Kane P, Murphy LA, Goldstein IJ, Fekety R.
    Journal: Clin Exp Immunol; 1979 Feb; 35(2):163-70. PubMed ID: 436334.
    Abstract:
    A time-space aggregate of Hodgkin's disease was observed in a small town. A large elevator for the storage of navy beans was located in the residential area of the town. Lymphocytes of town residents compared to those of non-residents showed increased levels of transformations when challenged with extracts of navy beans. A phytohaemagglutinin from navy beans with the ability to stimulate lymphocytes was isolated and characterized. A hypothesis concerning a connection between this cluster of Hodgkin's disease and the abnormal lymphocyte responses to navy-bean phytohaemagglutinin is discussed.
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