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  • Title: Concordant segregation of the expression of SV40 T antigen and human chromosome 7 in mouse-human hybrid subclones.
    Author: Croce CM, Koprowski H.
    Journal: J Exp Med; 1974 May 01; 139(5):1350-3. PubMed ID: 4363410.
    Abstract:
    Subcloning of Simian virus 40 (SV40) T antigen-positive mouse-human hybrids, derived from the fusion of mouse cells deficient in thymidine kinase with SV40-transformed Lesch Nyhan fibroblasts, resulted in their segregation into T antigen-positive and negative subclones. Positive correlation between the presence of human chromosome 7 and the expression of SV40 T antigen was established in the subclones examined. These results negate the possibility of a transfer of the SV40 genome to a mouse chromosome.
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