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  • Title: Effect of beta-propiolactone inactivation of polyoma virus on viral functions.
    Author: Brown A, Consigli RA, Zabielski J, Weil R.
    Journal: J Virol; 1974 Oct; 14(4):840-5. PubMed ID: 4370764.
    Abstract:
    Polyoma virus was inactivated by treatment with beta-propiolactone. T-antigen production, polyoma-RNA synthesis, induction of host DNA synthesis (measured by incorporation of labeled thymidine into the cell culture), and in vitro transforming ability were inactivated to a similar degree by various beta-propiolactone concentrations (0.25% beta-propiolactone reduced these functions approximately 96%), whereas plaque-forming ability and the ability of the virus to replicate its DNA and to synthesize capsid antigen were inactivated by a given concentration of beta-propiolactone to a much greater degree (0.25% beta-propiolactone led to a reduction of plaque-forming ability of over 8 logs). The significance of these data and their relationship to previously published experiments are discussed.
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