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  • Title: [Cerebral water and electrolytes during changes in the osmolarity and volume of the extracellular fluid].
    Author: Pinegin LE, Tibekina LM, Shakhmatova EI, Natochin Iu.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1979 Jan; 65(1):122-7. PubMed ID: 437191.
    Abstract:
    The increase of osmolarity in the blood serum after administration of polyethylenglycol-400 (PEG) as well as the sharp increase of the renal loss of fluid under the influence of furosemide insignificantly affected the water contents in the white and grey brain substance. A slight dehydration of the grey substance occured on combination of osmotic gradient effect and the renal loss of fluid. Preservation of initial hydration of the brain within the skull on administration of PEG and furosemide is due to redistribution of the fluid phases: dehydration of cells is followed by an increase in the volume of sodium-containing tissue fluid where upon the amount of sodium and calcium in the tissue practically does not change.
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