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  • Title: Effect of cyclic guanosine 3,5-monophosphate on the synthesis of enzymes sensitive to caatabolite repression in intact cells of Escherichia coli.
    Author: Artman M, Werthamer S.
    Journal: J Bacteriol; 1974 Nov; 120(2):980-3. PubMed ID: 4376146.
    Abstract:
    Cyclic guanosine 3',5'-monophosphate inhibits the synthesis of beta-galactosidase and tryptophanase in cultures of Escherichia coli growing in minimal media with glucose or glycerol as the carbon source. Cyclic guanosine 3',5'-monophosphate acts at the transcriptional level in the lac operon, it exerts its action at the promoter site of the operon, and requires the presence of functional cyclic adenosine 3',5'-monophosphate receptor protein.
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