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  • Title: Effect of macrophages on periodate-induced transformation of normal and chronic lymphatic leukaemia lymphocytes.
    Author: Biniaminov M, Ramot B, Novogrodsky A.
    Journal: Clin Exp Immunol; 1974 Feb; 16(2):235-42. PubMed ID: 4377711.
    Abstract:
    Human lymphocytes which have been purified from mononuclear leucocyte suspensions by removal of cells which adhere to nylon fibres have a reduced blastogenic response to periodate treatment as compared to the whole cell suspensions. Incubation of the purified lymphocytes on macrophage monolayers markedly enhanced their response to periodate. Periodate-treated macrophages enhance the response of purified lymphocytes to periodate more than do untreated macrophages. Stimulation of thymidine incorporation into purified lymphocytes untreated with periodate, was also noted after their incubation on periodate-treated macrophage monolayers. Chronic lymphatic leukaemia lymphocytes which have an impaired blastogenic response to periodate can be stimulated by this agent upon incubation on macrophage monolayers. Alternatively untreated chronic lymphatic leukaemia lymphocytes are stimulated on incubation on periodate-treated macrophage monolayers.
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