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  • Title: Sustained drug delivery systems. I. The permeability of poly(epsilon-caprolactone), poly(DL-lactic acid), and their copolymers.
    Author: Pitt CG, Jeffcoat AR, Zweidinger RA, Schindler A.
    Journal: J Biomed Mater Res; 1979 May; 13(3):497-507. PubMed ID: 438232.
    Abstract:
    The maximum steady state flux, diffusion coefficients, and solubilities of five contraceptive steroids in homopolymers and copolymers of epsilon-caprolactone and DL-lactic acid were determined. The permeabilities of polymers of epsilon-caprolactone were comparable to silicone rubber and, by inference, are suitable for the construction of drug delivery devices. Poly(DL-lactic acid) was 10(4) times less permeable, although its permeability was significantly enhanced by additives.
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