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  • Title: Unmasking of actual and potential receptor sites for cholera toxin in intestinal mucosal homogenates.
    Author: Gascoyne N, van Heyningen WE.
    Journal: J Infect Dis; 1979 Feb; 139(2):235-6. PubMed ID: 438537.
    Abstract:
    Endongenous and exogenous sialidases appear to unmask sialidase-stable and sialidase-labile gangliosides in intestinal mucosal homogenates by attacking glycoproteins. Exogenous (but not endogenous) sialidase then converts sialidase-labile gangliosides into the cholera toxin-binding, sialidase-stable ganglioside GM1 (galactosyl-N-acetylgalactosaminyl [sialosyl] lactosyl ceramide). Since Vibrio cholerae produces sialidase, these observations may be relevant to the course of cholera.
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