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  • Title: Effect of mazindol on brain dopamine turnover in spiperone-treated rats.
    Author: Fuller RW, Snoddy HD.
    Journal: J Neural Transm; 1979; 44(1-2):13-9. PubMed ID: 438800.
    Abstract:
    Mazindol, an anorexic drug, caused a large increase in brain 3, 4-dihydroxyphenylacetic acid (DOPAC) concentration in spiperone-pretreated rats. The increase was dose-related over a 1--10 mg/kg dose range of mazindol and was maximum within 1 hour after maxzindol injection into rats pretreated 1 hour previously with spiperone. In spiperone-pretreated rats, mazindol accelerated the disappearance of dopamine after the inhibition of dopamine synthesis by alpha-methyltyrosine. Mazindol apparently resembles amfonelic acid, methylphenidate, and cocaine in facilitating the impulse-mediated release of dopamine.
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