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  • Title: Inflammation in healing. 1. Time-course and mediation of exudation in wound healing in the rat.
    Author: Lykke AW, Cummings R.
    Journal: Br J Exp Pathol; 1969 Jun; 50(3):309-18. PubMed ID: 4389416.
    Abstract:
    The time-course of increased vascular permeability in excised wounds in the skin of the rat was measured by injecting Evan's blue i.v. at various times after wounding and extracting the dye which exuded into the injured tissues during various short intervals of time. A single peak of increased permeability occurred within the first hour after which exudation rapidly diminished to a low level which then persisted for at least 5 days after wounding. In animals with circulating colloidal carbon only venules in the edge and floor of wounds exhibited increased permeability during the phase of maximum exudation, after which leakage occurred only from capillaries in the advancing edge of the healing granulation tissue. In controlled experiments, using rats matched for weight, the exudation in the first 30 min. after wounding was partially suppressed by inhibitors of histamine and serotonin, but not by anti-inflammatory agents which inhibit the kinins and/or kallikrein. It is concluded that, in the absence of exogenous irritation, the inflammatory component of the process of healing after cutaneous wounding is evanescent, slight in magnitude, and mediated by histamine and serotonin.
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