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  • Title: [Postmenopausal estrogen and endometrial neoplasms].
    Author: Bengtsson LP.
    Journal: Lakartidningen; 1979 May 09; 76(19):1801-2. PubMed ID: 439977.
    Abstract:
    The risk of developing endometrial cancer from post-menopausal estrogen use is discussed. Post-menopausal estrogen use has increased in Sweden from 4% to 8% of women 45-54 years of age between 1973 and 1978. Studies have shown that the risk of developing endometrial cancer increases after 3 years of estrogen treatment. In Sweden most post-menopausal estrogen treatment is prescribed for less than 3 years, and the estrogens are prescribed in dosages just high enough to avoid unwanted side effects. No definite causal relationship has been established between post-menopausal estrogen use and the increased incidence of endometrial cancer. A risk-benefit analysis weighs the benefits of post-menopausal estrogen treatment against possible risks. Estrogens should be prescribed in as low dosages and for as short a time as possible to avoid possible risks.
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