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  • Title: Induction of benzo( )pyrene hydroxylase in human skin.
    Author: Levin W, Conney AH, Alvares AP, Merkatz I, Kappas A.
    Journal: Science; 1972 Apr 28; 176(4033):419-20. PubMed ID: 4402068.
    Abstract:
    Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[alpha]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[alpha]anthracene, a two- to fivefold increase in activity of benzo[alpha]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.
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