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  • Title: Unsuccessful treatment of acromegaly with medroxyprogesterone acetate.
    Author: Atkinson RL, Dimond RC, Howard WJ, Earll JM.
    Journal: Acta Endocrinol (Copenh); 1974 Sep; 77(1):19-25. PubMed ID: 4408390.
    Abstract:
    6 patients with active acromegaly were treated with 10 mg of medroxyprogesterone acetate (MPA) every 6 hours daily for 2 weeks to 6 months. Oral glucose tolerance tests, growth hormone (GH) levels, and insulin tolerance tests (ITT) were done before and during MPA treatment. Basal GH levels varied widely during control and therapy periods; no significant lowering of GH levels occurred during treatment. Carbohydrate tolerance was not significantly affected by MPA therapy, although 5 out of 6 patients had deterioration at least once during treatment. Blood glucose response to ITT was unchanged by MPA. MPA did not affect the clinical features of acromegaly. There was no consistent effect of MPA on insulin-induced or arginine-induced GH secretion. It is concluded that MPA is not an effective agent for treating acromegaly.
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