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  • Title: Breast cancer in premenopausal and postmenopausal women.
    Author: Stavraky K, Emmons S.
    Journal: J Natl Cancer Inst; 1974 Sep; 53(3):647-54. PubMed ID: 4412246.
    Abstract:
    In the effort to determine if the risk factors for breast cancer differed between premenopausal and postmenopausal women, a case control study was conducted. The study sample included 95 premenopausal and 278 postmenopausal women with breast cancer admitted to the Ontario Cancer Foundation Clinic in London, Canada during the June 1967 to February 1971 period. The controls were 106 premenopausal and 480 postmenopausal women with benign and malignant diseases of sites other than breast admitted to the same clinic during the same period. The breast cancer risk increased with increasing age at 1st pregnancy among postmenopausal women only. Among the prememopausal women, increased breast cancer was associated with early menarche. Late age at natural menopause was an important risk factor for postmenopausal women. The risk in women experiencing natural menopause over the age of 55 was 2.5 times as great as that of women undergoing menopause before age 40. A longer interval between age at menarche and age at 1st pregnancy increased the risk in both groups. Oral contraceptive use, or duration of use, did not increase the risk of breast cancer. Among oral contraceptive users, there was a trend toward greater risk with increasing age at 1st use of OCs.
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