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  • Title: Prostaglandin E2 induced abortion with vaginal suppositories in a contraceptive diaphragm.
    Author: Schulman H, Saldana L, Tsai T, Leibman T, Cunningham M, Randolph G.
    Journal: Prostaglandins; 1974 Aug 10; 7(3):195-205. PubMed ID: 4415347.
    Abstract:
    PGE2 (prostaglandin E2), 20 mgm vaginal suppositories were administered to 2 groups of women seeking termination of pregnancy. 1 group had the suppository inserted inside a contraceptive diaphragm. Statistical comparisons were carried out for instillation to abortion time, side effects, and intrauterine pressure parameters. The usage of the diaphragm significantly reduced side effects, and resulted in an instillation to abortion time of 12.8 + or - 2.3 hours with no failures. The quantitative analysis of the uterine pressure recordings revealed activity significantly different than that seen with intraamniotic or extraovular PGF2alpha. The development of uterine activity simulates that of normal labor in that elevation of resting pressure does not occur and maximum active pressure evolves slowly.
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