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  • Title: Pulmonary alveolar hypoxia: release of prostaglandins and other humoral mediators.
    Author: Said SI, Yoshida T, Kitamura S, Vreim C.
    Journal: Science; 1974 Sep 27; 185(4157):1181-3. PubMed ID: 4415382.
    Abstract:
    Hypoxic ventilation of isolated perfused cat lungs caused the frequent appearance in pulmonary perfusates of biologically active substances, which included prostaglandins or prostaglandin-like compounds. In anesthetized cats, inhibition of prostaglandin biosynthesis with infusions of aspirin (more than 50 milligrams per kilogram) reduced the pulmonary vasoconstrictor and bronchoconstrictor responses to hypoxic breathing.
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