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  • Title: Reduced haemolytic C1 activity in serum of hypogammaglobulinaemic chickens.
    Author: Gabrielsen AE, Linna TJ, Weitekamp DP, Pickering RJ.
    Journal: Immunology; 1974 Sep; 27(3):463-8. PubMed ID: 4415507.
    Abstract:
    Sera from hypogammaglobulinaemic chickens, aged 22–44 days, and age-matched controls were assayed for C1 haemolytic activity by three methods, two involving cell intermediates (EAIgMC4 and EAckC4) and the third an EAck and a guinea-pig R1. Total haemolytic complement (C) was also titrated using rabbit erythrocytes bearing chicken antibody. Immunoglobulin status was monitored by immunoelectrophoresis. C1 activity was reduced in the hypogammaglobulinaemic chickens by all three assay methods, and the differences were highly significant statistically. Total C also tended to be lowered in the hypogammaglobulinaemic group, but the depression was of borderline significance. Thus, hypogammaglobulinaemic chickens have a functional deficiency of C1 at least as pronounced as that of patients with X-linked recessive agammaglobulinaemia.
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