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  • Title: Lethal irradiation: treatment with immune cell populations.
    Author: Mandel MA.
    Journal: Ann Plast Surg; 1979 Mar; 2(3):213-8. PubMed ID: 44168.
    Abstract:
    Lethally irradiated mice have been successfully treated by the inoculation of allogeneic spleen cell populations, without the development of a secondary graft-versus-host (GVH) reaction. This has been accomplished by eliminating those cells responsible for GVH reaction, using a density gradient ultracentrifugation technique. The therapeutic potential for this technique is great. It may well provide a modus operandi to treat patients exposed to otherwise lethal doses of radiation, as well as facilitate therapy of patients with cancer and immune deficiency diseases.
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