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  • Title: [Adverse effects of oral contraceptives].
    Author: Gram LF.
    Journal: Ugeskr Laeger; 1974 Oct 14; 136(42):2361-6. PubMed ID: 4420288.
    Abstract:
    A study of 990 reports of side effects experienced by users of oral contraceptives between 1968-1974 is presented. The 3 most frequently reported side effects were thromboembolic distrubances, psychical disturbances, and weight gain. Thromboembolic distrubances were significantly more frequent with higher estrogen content. A correlation between estrogen content and psychical distrubances or weight gain could not be definitively shown due to changes in the use of the various brands of contraceptives and the decrease of reports about these side effects over the years. The frequency of side effects reported for selected single preparations were compared. A correlation was shown between the occurrence of weight gain and mental disturbance; the relationship showed no correlation to estrogen content and only a slight correlation to the gestagen component.
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