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  • Title: Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
    Author: Fu SM, Kunkel HG, Brusman HP, Allen FH, Fotino M.
    Journal: J Exp Med; 1974 Oct 01; 140(4):1108-11. PubMed ID: 4427089.
    Abstract:
    HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.
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