These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Analysis of nanogram quantities of norethisterone in plasma using a GC-MS-COM selective ion detection procedure.
    Author: Stillwell WG, Stillwell RN, Horning EC.
    Journal: Steroids Lipids Res; 1974; 5(2):79-90. PubMed ID: 4428492.
    Abstract:
    A procedure to detect and quantify nanogram amounts of the contraceptive steroid norethisterone (17alpha-ethinyl-17beta-hydroxy-4-estren-3-one) in human plasma is described. Norgestrel (racemic 13beta-ethyl-17alpha-ethinyl-17beta-hydroxy-4-gonen-3-one) was added to the plasma as an internal reference compound. Norethisterone and norgestrel were isolated from the plasma using a benzene and ammonium carbonate extraction procedure and were treated with trimethylsilylimidazole and potassium acetate to form TMS-enol TMS derivatives. Analyses of norethisterone and norgestrel were done by selective ion detection of the molecular ions using a combination of gas chromatography, mass spectrometry, and a computer.
    [Abstract] [Full Text] [Related] [New Search]