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  • Title: Comparison of prostaglandin F2alpha and hypertonic saline for induction of midtrimester abortion.
    Author: Lauersen NH, Wilson KH, Beling CG, Fuchs F.
    Journal: Am J Obstet Gynecol; 1974 Dec 01; 120(7):875-9. PubMed ID: 4429105.
    Abstract:
    20 healthy women between 18-20 weeks of gestation and seeking abortion were studied to compare the effects of prostaglandin F2alpha (PGF2) with those of instillation of saline solution and intravenous oxytocin. 9 out of 10 patients in the prostaglandin group aborted completely in about 15.16 hours. In only one of the prostaglandin patients did abortion have to be completed surgically. All of the 10 patients in the saline solution-oxytocin group also aborted completely, but with a mean time of 22.34 hours, a difference not statistically significant. The complication rate was higher in patients aborted with PGF2, including postabortion lactation and gastrointestinal effects, especially vomiting. In terms of hormonal changes, the similarities between the 2 groups were more numerous than the differences, suggesting that the 2 mechanics of abortion may not be totally different. Comparative studies on a much larger group of patients are desirable.
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