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  • Title: Modifying action of levamisole on the course of adjuvant-induced polyarthritis in rats.
    Author: Brajczewska-Fischer W, Szpilman H, Ryzèwska A.
    Journal: Arch Immunol Ther Exp (Warsz); 1979; 27(1-2):241-6. PubMed ID: 444037.
    Abstract:
    Treatment of August rats with levamisole (L-tetramisole) distinctly depressed the development and the course of adjuvant-induced polarthritis (A-pa). The depressing activity of the drug was dose-dependent. However, spontaneous stimulation of lymphocytes from A-pa rats treated with levamisole was decreased only after the first 7 days of treatment. Moreover, these lymphocytes showed no changes in PHA-reactivity in comparison with untreated animals. It was concluded that levamisole in some circumstances may show immunosuppressive activity; however, it did not seem to act directly on lymphocytes.
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