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  • Title: Disturbance of tryptophan metabolism and its correction during hormonal contraception.
    Author: Bennink HJ, Schreurs WH.
    Journal: Contraception; 1974 Apr; 9(4):347-56. PubMed ID: 4442280.
    Abstract:
    Blood pyrodoxine hydrochloride (vitamin-B6) concentration was determined in 50 women using combined oral contraceptives (OCs), 24 women who received an intramuscular injection of 150 mg medroxyprogesterone acetate (MPA) every 12 weeks, and in 14 women who used an intrauterine device (IUD) at the out-patient contraception unit of the University Hospital in Utrecht. Urinary xanthurenic acid (XA) excretion 8 hours following oral administration of 2 gm L-tryptophan was determined in 100 women using OCs containing estrogens, in 15 women receiving 150 mg MPA and in 52 women using IUDs. Vitamin B6 blood concentration was not affected by OCs or MPA. OCs increased XA excretion after tryptophan administration in 80% of the users (controls: 40 mcmole/8 hours compared with 235 mcmole/8hours). When Neogynon or Stedirel-d OC was used, the disturbance in tryptophan metabolism increased during the second year (p less than .01). With Lyndiol, maximum disturbance occurred in 1 year. Vitamin-B6 decreased XA excretion after 2 gm tryptophan in 38 women on OCs (p less than .01). Normalization of the excretion was achieved by giving 100 mg vitamin- B6/24hours for 4 weeks. The authors suggest routine vitamin-B6 administration during hormonal contraception.
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