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  • Title: Prevention of suxamethonium-induced changes in serum potassium concentration by hexafluorenium. Is their combined use justified?
    Author: Radnay PA, Badola RP, Dalsania A, El-Gaweet EI, Duncalf D.
    Journal: Br J Anaesth; 1979 May; 51(5):447-51. PubMed ID: 444345.
    Abstract:
    Sixty patients, none of whom was suffering from renal failure, received neurolept anaesthesia. They were divided into six groups of 10 patients each. Groups I and IV, II and V, and III and VI were given suxamethonium 0.2, 0.6 and 1.0 mg kg-1 respectively. Groups IV-VI were pretreated with hexafluorenium 0.3 mg kg-1. The serum potassium concentration decreased significantly after the induction of anaesthesia and also following the administration of hexafluorenium. Neither suxamethonium 0.2 mg nor 0.6 mg kg-1 with or without hexafluorenium restored the potassium concentration to the control value. Suxamethonium 1.0 mg kg-1 alone caused the serum potassium to increase to values greater than control; hexafluorenium attenuated this effect. The combination of hexafluorenium and suxamethonium may be of benefit in patients who are anephric or are in chronic renal failure.
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