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  • Title: Potentiation of anticancer agent cytotoxicity against sensitive and resistant AKR leukemia by amphotericin B1.
    Author: Valeriote F, Medoff G, Dieckman J.
    Journal: Cancer Res; 1979 Jun; 39(6 Pt 1):2041-5. PubMed ID: 445402.
    Abstract:
    Amphotericin B was able to enhance the effects of actinomycin D (Act-D), adriamycin, and vincristine against AKR leukemia. AKR leukemia lines of increasing resistance to Act-D were obtained by passage in syngeneic mice treated with Act-D. The cells selected for Act-D resistance also eventually became cross-resistant to vincristine and Adriamycin, but resistance to these agents developed at a slower rate. Amphotericin B enhanced the effects of all these agents against the resistant cells, although the degree of enhancement varied among these antitumor agents and decreased as drug resistance increased in the late-passage leukemia lines.
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