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  • Title: Calcium transport and translocation of adenine nucleotides in mitochondria from Morris hepatoma 3924A.
    Author: Eboli ML, Malmström K, Galeotti T, López-Alarcón L, Carafoli E.
    Journal: Cancer Res; 1979 Jul; 39(7 Pt 1):2737-42. PubMed ID: 445477.
    Abstract:
    The interaction of Ca2+ with Morris hepatoma 3924A mitochondria and its effect on the adenine nucleotide translocation have been studied. The characteristics of the Ca2+ transport process in mitochondria from Morris hepatoma are not significantly different from those of normal liver mitochondria. The Km for Ca2+ is 2 to 3 microM, and the rate versus concentration curve exhibits hyperbolic kinetics. A lower activity of the adenine nucleotide translocation was found, probably due to the high endogenous Ca2+ content of Morris hepatoma mitochondria (123 +/- 15 nmol Ca2+ per mg protein). No further inhibition of the translocase activity was observed after isolated mitochondria had accumulated extra amounts of Ca2+. The total amount of adenine nucleotides in tumor mitochondria is one-half those present in control liver, and a significantly lower percentage of the pool is present as adenosine 5'-monophosphate.
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