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  • Title: Ribonuclease-sensitivity of covalently closed rat liver mitochondrial deoxyribonucleic acid.
    Author: Lonsdale DM, Jones IG.
    Journal: Biochem J; 1974 Jul; 141(1):155-8. PubMed ID: 4455198.
    Abstract:
    Preparations of covalently closed mitochondrial DNA of rat liver contain 10-30% of molecules that are converted into relaxed circular molecules after treatment with ribonuclease. Control experiments, with covalently closed bacteriophage PM2 DNA, indicate that ribonuclease-sensitivity cannot be induced either by depurination or by incubation with reducing agents.
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