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  • Title: [Intravenous administration of prostaglandin F2alpha or prostaglandin E2 in labor pain induction in fetal death].
    Author: Klausch B, Kruse HJ, Junge WD, Göretzlehner G.
    Journal: Zentralbl Gynakol; 1974 Nov 29; 96(48):1505-13. PubMed ID: 4458350.
    Abstract:
    Successful treatment of intrauterine fetal death by intravenous administration of (PGF2alpha) prostaglandin F2alpha in 20 patients (gestational age 22-40 weeks) and of PGE2 in 6 patients (gestational age 24-36 weeks) is reported. Infusion of 5-20 mcg PGF2alpha/minute and of 0.5-2.0 mcg PGE2/minute resulted in regular uterine contractions within the first 2 hours. The average dosage of PGF2alpha was 7.06 mg in cephalic presentations (infusion time=7 hours, 2 minutes) and 23.4 mg in anomalous presentations (infusion time=16 hours, 54 minutes). The average dose of PGE2 was 1.17 mg (infusion time=9 hours, 23 minutes). Coagulation investigations were performed before, during, and after PG infusion. These investigations suggest that the coagulation potential of patients with intratuerine fetal death by intravenous PG administration is not influenced to any extent. Few undesirable side effects were seen using this PG. We consider that the intravenous PG application for the induction of labor in intrauterine fetal death is a useful method because of the effectiveness and few undersirable side effects. (author's)
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