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  • Title: Molecular forms of cobalt-activated acylase in human tissues and serum of patients with viral hepatitis.
    Author: Ziomek E, Słowińska R, Szewczuk A.
    Journal: Clin Chim Acta; 1979 Apr 16; 93(2):189-94. PubMed ID: 445840.
    Abstract:
    Two molecular forms of cobalt-activated acylase present in human tissues and one or three in sera of patients with viral hepatitis were noted. They have different substrate specificity. Only form 2 is strongly inhibited by alpha-hydroxyisocaproyl-tyrosine and -phenylalanine. Electrophoretic migrations of all enzyme forms are different from those of aminoacylase. Immunoglobulin antiform 2 of the acylase does not precipitate other forms of cobalt-activated acylase or aminoacylase.
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