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  • Title: Effect on nitrous oxide on the anaesthetic requirement of enflurane.
    Author: Torri G, Damia G, Fabiani ML.
    Journal: Br J Anaesth; 1974 Jul; 46(7):468-72. PubMed ID: 4458769.
    Abstract:
    The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25-36 min in order to equilibrate the brain with the alveolar anasthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used.
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